APC at a glance.

نویسنده

  • Inke Näthke
چکیده

The gene encoding the adenomatous polyposis coli protein (APC) is mutated in most colon cancers. The major role of APC is thought to be as a scaffold for a protein complex that regulates the phosphorylation and thus degradation of β-catenin in the WNT signalling pathway (Huelsken and Behrens, 2002). However, there is increasing evidence that dysregulation of β-catenin is not the only effect of mutations in APC relevant to the development of cancer and that interactions between APC and cytoskeletal proteins are also important.

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عنوان ژورنال:
  • Journal of cell science

دوره 117 Pt 21  شماره 

صفحات  -

تاریخ انتشار 2004